The bioXclusters+ alliance, supported from 2016 to 2018, gathers 4 European Life Sciences / health clusters: Biocat (Catalonia), BioM (Bavaria), BioPmed (Piedmont), Lyonbiopole (Auvergne Rhone-Alpes). It aims to address the next-decade European challenges related to healthcare and SMEs growth, thanks to a common vision of personalised healthcare as the paradigm for future global healthcare solutions. To address this new paradigm, the bioXclusters+ partnership intends to be the most competitive European meta-cluster initiative in personalised healthcare, delivering at global level cutting edge solutions through its innovation ecosystem and offering an entry point for global players to Europe. In this regard, the consortium internationalisation strategy plan to focus their activities on three countries already explored (US, China and Brazil) but also on additional markets such as Japan. The approach consists in confirming its position at European and international scene in gaining visibility inside and outside Europe; reinforcing trustful relations with target countries building Gateways; deploy common internationalisation tools and tailored supported to European SMEs based on the mutual competence knowledge and long term relationship developed within the alliance. Furthermore the alliance will focus their action on addressing the challenges related to the global healthcare sector, such as the inclusion of technologies such as big data, micro and nanotechnologies, ICT for the development of systemic and practical solutions addressing the industry competitiveness and the patients' needs. This is the reason why collaboration with other key players (such as other ESCPs and other EU initiatives) in the sector mentioned above will be deploy.